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KMID : 0381920080380030195
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Korean Journal of Microscopy
2008 Volume.38 No. 3 p.195 ~ p.204
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The Effect of Lithospermum erythrorhizon Extracts in UVB-Irradiated Mouse Skin
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Song Seon-Young
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Abstract
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This study was intended to identify the effectiveness of Lithospermum erythrorhizon in the UVB-irradiated mouse skin. The C57BL mice were divided into three groups; the control group, the UVB irradiated group (UVB group), and the group treated with Lithospermum erythrorhizon extracts after UVB irradiation (UVB+Le group). 10 mouses were collected and sacrificed at 24 hrs, 48 hrs, 72 hrs, 120 hrs, and 168 hrs, respectively. In the result, the transepidermal water loss (TEWL) was decreased the UVB+Le group than UVB groups by time. At the 168 hrs group was significantly lower (p?0.05). In the result, the melanin value was decreased in the UVB+Le group than UVB group, but meaningless (p¤0.05). In the result of erythema index, the UVB+Le group was meaningfully lower at 24 hrs, 48 hrs, and 72 hrs group than UVB group (p?0.05). In the result of scanning electron micrograph observation, the UVB+Le group was allevited swelling than UVB group at the 24 hrs, formation of the scab at the 48 hrs, regular plate shap at the 72 hrs, new keratin observated at the 120 hrs partially, and fine fiber covered epidermis surface at the 168 hrs. In the result of transmission electron micrograph observation, the UVB+Le group was facilitation of increased lamellar bodies and reformation lamellar bodies than UVB group at the all groups. Almost all the structures were recovered at the 168 hrs group. In conclusion, Lithospermum erythema extracts may recovery on the UVB-irradiated mouse skin.
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KEYWORD
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UVB, Lithospermum erythrorhizon, Transepidermal water loss, Melanin value, Erythema index, TEM
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